| CAS NO: | 2410557-00-3 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 2410557-00-3 |
| Canonical SMILES | O=C(NCC1)C2=CC(F)=CC3=C2C1=C(C4=CC=C(C=C4)CN(CCOCCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)C)N3 |
| 分子式 | C46H55FN6O11 |
| 分子量 | 886.96 |
| 溶解度 | DMSO: 50 mg/mL (56.37 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using thePROTAC approach. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1[1]. [1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec;15(12):1223-1231. |
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