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ENPP1 Inhibitor C
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ENPP1 Inhibitor C图片
CAS NO:2378640-92-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
ENPP1 Inhibitor C (Compound C) 是一种有效的 ENPP1(外核苷酸焦磷酸酶/磷酸二酯酶 1)抑制剂,IC50 值为 0.26、0.48 和 2.0 μM 分别通过 TG-mAMP、pNP-TMP 和 ATP 测定法评估。 TG (Tokyo Green)-mAMP:一种新合成的灵敏 ENPP1 荧光探针。
Cas No.2378640-92-5
Canonical SMILESNC1=CC=CC(CC2=C(N(C)C)N3C(N=C2C)=NC=N3)=C1
分子式C15H18N6
分子量282.3
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ENPP1 inhibitor C is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50 = 0.26 μM in a cell-free assay).1 It is selective for ENPP1 over ENPP2-7 at 10 μM. ENPP1 inhibitor C decreases ENPP1 activity in MDA-MB-231 human breast and C6 rat glioma cancer cells when used at a concentration of 10 μM.

|1. Kawaguchi, M., Han, X., Hisada, T., et al. Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging, and prognostic assessment of malignant breast cancer. J. Med. Chem. 62(20), 9254-9269 (2019).