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VO-OHpic
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VO-OHpic图片
CAS NO:675848-25-6
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
VO-OHPic 是一种可逆的、非竞争性的、选择性的 PTEN 抑制剂,IC50 为 46 nM。
Cas No.675848-25-6
Canonical SMILES[O-][V]=O.OC(=O)C1=C(O)C=CC=N1.OC(=O)C1=C(O)C=CC=N1
分子式C12H10N2O8V
分子量361.16
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.

Rosivatz et al (2006) A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol. 1 780 PMID:17240976 |Sharma et al (2015) The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv. 1 e1500845 PMID:26601142