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CX08005
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CX08005图片
CAS NO:1256341-22-6
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
Cas No.1256341-22-6
Canonical SMILESCCCCCCCCCCCCCCOC1=C(C=CC=C1)NC(C2=C(C(O)=O)C=CC=C2)=O
分子式C28H39N04
分子量453.61
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.

Zhang et al (2016) A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for Ins resistance. Br.J.Pharmacol. 173 1939 PMID:26990621