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PKUMDL WQ 2201
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PKUMDL WQ 2201图片
CAS NO:592474-91-4
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
Cas No.592474-91-4
Canonical SMILESCCNC(N/N=C/C1=CC=C(C2=CC(Cl)=C(C(O)=O)C=C2)O1)=S
分子式C15H14ClN3O3S
分子量351.81
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.

Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID:28042046