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AMI5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AMI5图片
CAS NO:17372-87-1
包装:100mg
市场价:389元

产品介绍
曙红 Y(二钠)是一种可溶性酸性红色染料分子。
Cas No.17372-87-1
别名水溶伊红,Acid Red 87
化学名sodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate
Canonical SMILESBrC1=C([O-])C(Br)=C2C(C(C3=CC=CC=C3C([O-])=O)=C4C=C(Br)C(C(Br)=C4O2)=O)=C1.[Na+].[Na+]
分子式C20H6Br4Na2O5
分子量691.85
溶解度≥ 69.2mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 0.78 and 1.41 μM for Hmt1p and PRMT1, respectively

AMI5 is a non-selective protein methyltransferase inhibitor.

Post-translational protein methylation at lysine and arginine residues is related to the gene expression regulation. The enzymatic activities of protein methyltransferases serve to do covalent modifications in the control of gene transcription.

In vitro: AMI-5 has been identified as a competitive inhibitor of SAM binding and had been shown to inhibit not only PRMTs but also lysine methylation by the Set7 and disruptor of telomeric silencing 1-like (DOT1L) MTases in vitro. Both AMI-5 and its analog AMI-1 have been used as lead compounds for the development of novel MTase-specific inhibitors. Moreover, it was found that AMI-5 could inhibit Set7 in vitro and decrease H3K4m1 in vascular endothelial cells. [1].

In vivo: Currently, there is no animal study reported.

Clinical trial: Up to now, AMI-5 is still in the preclinical development stage.

Reference:
[1] Okabe J,Fernandez AZ,Ziemann M,Keating ST,Balcerczyk A,El-Osta A.  Endothelial transcriptome in response to pharmacological methyltransferase inhibition. ChemMedChem.2014 Aug;9(8):1755-62.