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Adox
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Adox图片
CAS NO:34240-05-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Adox 是一种嘌呤核苷类似物,是 S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM) 的有效抑制剂。 Adenosine Dialdehyde 在体内表现出有效的抗肿瘤活性,可用于癌症研究。
Cas No.34240-05-6
别名腺苷二醛
化学名2-(1-(6-amino-9H-purin-9-yl)-2-oxoethoxy)-3-hydroxypropanal
Canonical SMILESO=C(C(OC(CO)C([H])=O)N1C=NC2=C1N=CN=C2N)[H]
分子式C10H11N5O4
分子量265.23
溶解度10mg/mL in DMSO, or in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Adenosine dialdehyde (AdOx) has been identified as an indirect methyltransferase inhibitor.

Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues.

In vitro: Previous cell-based study showed that the treatment of cells with the methyltransferase inhibitor adenosine dialdehyde (AdOx) could lead to cell cycle arrest and death in different tested cell types. In addition, the e form of cell death and phenotypical outcom was found to be strikingly dependent on the concentration of AdOx. Results showed that lower AdOx concentrations could result in a G2 arrest and predominantly cause apoptosis, which was measured by biochemical and morphological criteria. In contrast, higher concentrations of AdOx led to a novel and so far undescribed form of cell death that was characterized by distinct, caspase-independent alterations of the cell shape with a marked protuberation of the nucleus, actin aggregation, cytoplasmic extensions, as well as incomplete chromatin condensation [1].

In vivo: So far, there is no animal data reported.

Clinical trial: Up to now, AdOx is still in the preclinical development stage.

Reference:
[1] Schwerk C, Schulze-Osthoff K. Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death. Oncogene.2005 Oct 27;24(47):7002-11.