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PRL-3 Inhibitor
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
PRL-3 Inhibitor图片
CAS NO:893449-38-2
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
PRL-3 Inhibitor 是一种有效的 PRL-3 抑制剂，IC50 为 0.9 μM。 PRL-3 Inhibitor 在基于细胞的测定中显示出减少的侵袭。
Cas No.893449-38-2
别名BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor
化学名5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone
Canonical SMILESBrC1=CC=C(OCC2=C(Br)C=CC=C2)C(/C=C3C(NC(S\3)=S)=O)=C1
分子式C17H11Br2NO2S2
分子量485.2
溶解度≤16mg/ml in DMSO;16mg/ml in dimethyl formamide
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Phosphatase of regenerating liver 3 (PRL-3; also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases.[1],[2] It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay.[1] PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin β1 and modulates VEGF-mediated endothelial cell migration.[3],[4] It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines.[5],[6]

Reference:
[1]. Ahn, J.H., Kim, S.J., Park, W.S., et al. Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors. Bioorganic & Medicinal Chemistry Letters 16(11), 2996-2999 (2006).
[2]. Min, G., Lee, S.K., Kim, H.N., et al. Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells. Bioorganic & Medicinal Chemistry Letters 23(13), 3769-3774 (2013).
[3]. Tian, W., Qu, L., Meng, L., et al. Phosphatase of regenerating liver-3 directly interacts with integrin β1 and regulates its phosphorylation at tyrosine 783. BMC Biochemistry 13:22, (2012).
[4]. Zimmerman, M.W., McQueeney, K.E., Isenberg, J.S., et al. Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. The Journal of Biological Chemisty 289(9), 5904-5913 (2014).
[5]. Ooki, A., Yamashita, K., Kikuchi, S., et al. Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer. BMC Cancer 11:122, (2011).
[6]. Zhou, J., Bi, C., Chng, W.J., et al. PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy. PLoS One 6(5), (2011).