CAS NO: | 13408-09-8 |
包装 | 价格(元) |
25g | 电议 |
100g | 电议 |
500g | 电议 |
Cas No. | 13408-09-8 |
别名 | 五水β-甘油磷酸钠(二钠五水合物) |
化学名 | 2-(dihydrogen phosphate)-1,2,3-propanetriol, disodium salt, pentahydrate |
Canonical SMILES | [O-]P(OC(CO)CO)([O-])=O.[Na+].[Na+].O.O.O.O.O |
分子式 | C3H7O6P o 2Na [5H2O] |
分子量 | 306.1 |
溶解度 | ≥ 30.7mg/mL in Water, ≥ 14.3mg/mL in DMSO |
储存条件 | 4°C, protect from light |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor [1]. Protein phosphatase is an enzyme that removes a phosphate group from the phosphorylated amino acid residue of its target protein. Protein phosphorylation is one of the most common protein posttranslational modifications. β-Glycerophosphate is a potent protein phosphatase inhibitor that acts as a phosphate group donor in bone cell mineralization studies [1][3]. In MC3T3-E1, ROS 17/2.8, and chick osteoblast-like cells, β-Glycerophosphate did not affect the rate of anaerobic glycolysis, but increased the medium Pi levels, suggesting that β-Glycerophosphate was hydrolyzed by bone cells. The local increase in medium Pi concentration promoted rapid mineral deposition [1]. In human bone marrow stromal cells (HBMSC) and human osteoblasts (HOB), BMP-2 resulted in mineralization of their matrix in the presence of beta-glycerophosphate and ascorbic acid [3]. β-Glycerophosphate (10 mM) also accelerated calcification of cultured vascular smooth muscle cells through an alkaline phosphatase-related mechanism [4]. References: |