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MBM-17
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MBM-17图片
CAS NO:2083621-90-1
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
MBM-17 (compound 42c) 是有效的 NIMA-related kinase 2 (Nek2) 抑制剂，IC50 值为 3 nM，通过诱导细胞周期停滞和凋亡，抑制癌细胞的增殖，具有抗肿瘤活性，且对小鼠没有明显的毒性。
Cas No.2083621-90-1
Canonical SMILESNC(C(C=C1)=C(OCC2=CC=CC=C2)C=C1C3=CN=C4N3C=CC(C5=CN(CCN(C)C)N=C5)=C4)=O
分子式C28H28N6O2
分子量480.56
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1]. IC50: 3 nM (Nek2), 5800 nM (Aurora A)[1]

MBM-17 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.48, 1.06, 4.53 μM, respectively[1].

[1]. Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.