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Mcl1-IN-11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mcl1-IN-11图片
CAS NO:2042211-13-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Mcl1-IN-11 (Compound G) 是一种选择性的 Mcl-1 抑制剂,对 Bcl-2 的作用较弱,Ki 值分别为 0.06 和 4.2 μM。
Cas No.2042211-13-0
Canonical SMILESCC1(C)C2=CC(C)=C(C(C3=CC=C(C(NS(=O)(C4=CC=C(NCCSC5=CC=CC=C5)C([N+]([O-])=O)=C4)=O)=O)C=C3)=C)C=C2C(C)(C)CC1
分子式C38H41N3O5S2
分子量683.88
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively[1]. Ki: 0.06 (Mcl-1), 4.2 μM (Bcl-2)[1]

[1]. Wang M, et al. Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5207-5211.