Nitroaspirin

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Nitroaspirin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

175033-36-0

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

Nitroaspirin (NCX 4016) 是一氧化氮 (NO) 供体和阿司匹林的硝基衍生物，Aspirin 与 Nitroaspirin 联合以抑制环加氧酶。Nitroaspirin (NCX 4016) 具有抗血栓形成和抗血小板特性，并作为 COX-1 的直接和不可逆抑制剂。Nitroaspirin (NCX 4016) 通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白，在顺铂耐药人卵巢癌细胞中引起细胞周期停滞和凋亡。

Cas No.	175033-36-0
别名	2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016
Canonical SMILES	O=C(OC1=CC=CC(CO[N+]([O-])=O)=C1)C2=CC=CC=C2OC(C)=O
分子式	C₁₆H₁₃NO₇
分子量	331.28
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4]. COX-1 [1]. Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8. [2]. Bertuglia S, et al. Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheekpouch microcirculation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G437-43. [3]. Corazzi T, et al. Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7. [4]. Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8.