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Taurodeoxychloic Acid sodium hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Taurodeoxychloic Acid sodium hydrate图片
CAS NO:110026-03-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议
100mg电议
200mg电议

产品介绍
Taurodeoxychloic Acid sodium hydrate (Sodium taurodeoxycholate monohydrate) 是一种胆汁酸,是一种由肝脏中的胆固醇合成的两亲表面活性剂分子。
Cas No.110026-03-4
别名牛磺猪去氧胆酸,Sodium taurodeoxycholate monohydrate
Canonical SMILESC[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C.[Na+].O
分子式C26H47NNaO7S+
分子量540.71
溶解度DMSO: 125 mg/mL (231.61 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Taurodeoxychloic Acid (sodium hydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxychloic Acid (sodium hydrate) is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis[1]. Caspase-12

Taurodeoxychloic Acid (TUDCA) is neuroprotective in a transgenic animal model of Huntington's disease[2].

[1]. Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep;36(3):592-601. [2]. Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10671-6.