Asperglaucide is an amide originally isolated fromP. aurantiacumthat has diverse biological activities, including anti-inflammatory, antibacterial, antioxidant, and anticancer properties.^1,2,3,4Asperglaucide inhibits production of nitric oxide (NO), prostaglandin E₂, and IL-1β in LPS-stimulated BV-2 microglial cells (IC₅₀s = 49.7, 51.5, and 40.4 µM, respectively).²It is active against Gram-negative bacteria (MICs = 0.05-0.10 mg/ml) and has antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl and Trolox equivalent antioxidant capacity (TEAC) assays (EC₅₀s = 9.51-78.81 µg/ml).³Asperglaucide decreases viability of U87 and U251 cancer cellsin vitrowhen used at concentrations ranging from 10 to 100 µM and reduces tumor growth when administered at a dose of 1 mgviaintratumoral injection in a U87 mouse xenograft model.⁴

1.Banerji, A., and Ray, R.Aurantiamides: A new class of modified dipeptides from Piper aurantiacumPhytochemistry20(9)2217-2220(1981) 2.Yoon, C.S., Kim, D.C., Lee, D.S., et al.Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: Inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cellsInt. Immunopharmacol.23(2)568-574(2014) 3.Tamokou, J.D., Simo Mpetga, D.J., Keilah Lunga, P., et al.Antioxidant and antimicrobial activities of ethyl acetate extract, fractions and compounds from stem bark of Albizia adianthifolia (Mimosoideae)BMC Complement. Altern. Med.1299(2012) 4.Yang, Y., Zhang, L.H., Yang, B.X., et al.Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic fluxJ. Cell. Mol. Med.19(5)1055-1064(2015)