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Atorvastatin-d5(calcium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Atorvastatin-d5(calcium salt)图片
CAS NO:222412-82-0
包装与价格：
包装价格(元)
500 μg电议
1mg电议

产品介绍
An internal standard for the quantification of atorvastatin
Cas No.222412-82-0
别名阿托伐他汀 d5 (1/2钙盐)
Canonical SMILESO=C(C1=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C2=CC=C(F)C=C2)=C1C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NC4=CC=CC=C4.[Ca+2]
分子式C29H30D5FN2O5.1/2Ca
分子量582.7
溶解度DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: 0.50 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Atorvastatin-d5is intended for use as an internal standard for the quantification of atorvastatin by GC- or LC-MS. Atorvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol synthesis, that has IC50values of 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively.1Formulations containing atorvastatin have been used in the treatment of hypercholesterolemia and certain dyslipidemias.

1.Shaw, M.K., Newton, R.S., Sliskovic, D.R., et al.Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductaseBiochem. Biophys. Res. Commun.170(2)726-734(1990)