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VRK-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
VRK-IN-1图片
CAS NO:2378855-09-3
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
VRK-IN-1 是一种有效和选择性的牛痘相关激酶 1 (VRK1) 抑制剂，IC50 值为 150 nM。VRK1 是与细胞分裂增加和神经系统疾病相关的人类 Ser/Thr 蛋白激酶。
Cas No.2378855-09-3
分子式C18H11F4NO2
分子量349.28
溶解度DMSO : 100 mg/mL (286.30 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1].

VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM[1].VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM[1].

[1]. Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271.