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U-0521
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
U-0521图片
CAS NO:5466-89-7
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
U-0521 是儿茶酚-O-甲基转移酶 (COMT) 的抑制剂。U-0521具有研究帕金森病的潜力。
Cas No.5466-89-7
分子式C10H12O3
分子量180.2
溶解度DMSO : 100 mg/mL (554.94 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT). U-0521 has the potential for the research of Parkinson’s disease[1].

U-0521 inhibits RBC COMT activity in a dose-dependent manner with an IC50 of 6 x10-6 M[1].

U-0521 (i.p.; 0-250 mg/kg; 10 min) inhibits COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity is obtained at 90 mg/kg and maximum inhibition of 90% is obtained at 250 mg/kg[1].

[1]. Reches A, et al. Effect of 3’,4’-dihydroxy-2-methyl-propriophenone (U-0521) on catechol-O-methyltransferase activity and on DOPA accumulation in rat red blood cells and corpus striatum. Biochem Pharmacol. 1982;31(21):3415-3418.