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Tremelimumab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:745013-59-6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Tremelimumab (Ticilimumab) 是一种完全人源化的单克隆抗体,对细胞毒性 T 淋巴细胞抗原 4 (CTLA-4) 具有特异性,可用于转移性黑色素瘤研究。
Cas No.745013-59-6
别名CTLA-4单抗,Ticilimumab; CP-675206
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tremelimumab (Ticilimumab) is a fully humanized monoclonal antibody specific for cytotoxic T-lymphocyte antigen-4 (CTLA-4) and can be used for metastatic melanoma research[1].

Tremelimumab (Ticilimumab) has a higher affinity for CTLA-4-Ig than for CD28-Ig and that the antibody is specific for cynomolgus monkeys and humans[1].Tremelimumab does not bind to human leukocyte FcγR and does not trigger the release of cytokines avoiding the cytokine release syndrome, but increases the IL-2 production upon stimulation with the staphylococcal enterotoxin A in a concentration-dependent manner[1].Tremelimumab enhances the IL-2 production in T-cells[1].

[1]. Comin-Anduix B, et al. Tremelimumab: research and clinical development. Onco Targets Ther. 2016 Mar 23;9:1767-76.