| CAS NO: | 1246818-18-7 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 1246818-18-7 |
| 别名 | 托伐普坦 D7 |
| Canonical SMILES | O=C(NC1=CC(C)=C(C(N2C(C=CC(Cl)=C3)=C3C(O)CCC2)=O)C=C1)C4=C(C([2H])([2H])[2H])C([2H])=C([2H])C([2H])=C4[2H] |
| 分子式 | C26H18ClD7N2O3 |
| 分子量 | 456 |
| 溶解度 | DMSO: slightly soluble,Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tolvaptan-d7is intended for use as an internal standard for the quantification of tolvaptan by GC- or LC-MS. Tolvaptan is a nonpeptide vasopressin V2receptor antagonist (IC50= 3 nM for rat receptor) and a diuretic agent.1It is selective for V2over V1receptors (IC50= 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.2Formulations containing tolvaptan have been used to treat hyponatremia. 1.Kondo, K., Ogawa, H., Yamashita, H., et al.7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl ]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonistBioorg. Med. Chem.7(8)1743-1754(1999) 2.Yamazaki, T., Nakamura, Y., Shiota, M., et al.Tolvaptan attenuates left ventricular fibrosis after acute myocardial infarction in ratsJ. Pharmacol. Sci.123(1)58-66(2013) |
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