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Thromboxane B2-d4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Thromboxane B2-d4图片
CAS NO:1346112-79-5
包装与价格：
包装价格(元)
25 μg电议
50 μg电议
100 μg电议
500 μg电议

产品介绍
An internal standard for the quantification of thromboxane B2d4
Cas No.1346112-79-5
Canonical SMILESO[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)OC(O)C1
分子式C20H30D4O6
分子量374.5
溶解度DMF: >50 mg/ml (from TXB2),DMSO: >25 mg/ml (from TXB2),Ethanol: >100 mg/ml (from TXB2),PBS pH 7.2: >100 μg/ml (from TXB2)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thromboxane B2-d4(TXB2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of TXB2by GC-or LC-mass spectrometry. TXB2is a stable, biologically inert metabolite formed from the non-enzymatic hydrolysis of TXA2, which has a half-life of about 30 seconds.1Urinary analysis of TXB2accurately reflects intrarenal TXA2synthesis,2while measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA2secretion.3,4

1.Needleman, P., Moncada, S., Bunting, S., et al.Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxidesNature261(5561)558-560(1976) 2.Patrono, C., Ciabattoni, G., Patrignani, P., et al.Evidence for a renal origin of urinary thromboxane B2 in health and diseaseAdv. Prostaglandin Thromboxane Leukot. Res.11493-498(1983) 3.Lawson, J.A., Patrono, C., Ciabattoni, G., et al.Long-lived enzymatic metabolites of thromboxane B2 in the human circulationAnal. Biochem.155(1)198-205(1986) 4.Patrono, C., Ciabattoni, G., Pugliese, F., et al.Estimated rate of thromboxane secretion into the circulation of normal humansJ. Clin. Invest.77(2)590-594(1986)