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TH5427
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TH5427图片
CAS NO:2253744-56-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
TH5427 是一种很有前途的靶向抑制剂,可用于进一步研究 NUDT5 活性和 ADP-核糖代谢。TH5427 阻断孕激素依赖性、PAR 衍生的核 ATP 合成以及随后的乳腺癌细胞染色质重塑、基因调控和增殖。NUDT5 最近被确定为乳腺癌细胞激素依赖性基因调控和增殖的变阻器。
Cas No.2253744-56-6
分子式C20H20Cl2N8O3
分子量491.33
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells[1].

[1]. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250.