您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Brassicasterol
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Brassicasterol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Brassicasterol图片
CAS NO:474-67-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
芸苔甾醇是麦角甾醇的一种代谢产物,通过雄激素信号传导抑制膀胱癌的发生。
Cas No.474-67-9
别名油菜甾醇
化学名ergosta-5,22E-dien-3β-ol
Canonical SMILESCC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)C3=CC[C@@]21C
分子式C28H46O
分子量398.7
溶解度DMF: 2 mg/ml,DMSO: 0.1 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Brassicasterol is a phytosterol found in canola and rapeseed oils, marine algae, and shellfish.[1] It inhibits recombinant sterol Δ24-reductase with a Ki value of 42.7 μM in vitro. Brassicasterol increases accumulation of demosterol, a cholesterol precursor and substrate of sterol Δ24-reductase, and inhibits cholesterol formation in HL-60 cells in a dose-dependent manner. It also inhibits the hemolytic activity of pneumolysin from S. pneumoniae without affecting bacterial growth at concentrations up to 1,000 μg/ml.[2]

Reference:
[1]. Fernández, C., Suárez, Y., Ferruelo, A.J., et al. Inhibition of cholesterol biosynthesis by Δ22-unsaturated phytosterols via competitive inhibition of sterol Δ24-reductase in mammalian cells Biochem. J. 366(Pt 1), 109-119 (2002).
[2]. Li, H., Zhao, X., Deng, X., et al. Insights into structure and activity of natural compound inhibitors of pneumolysin Sci. Rep. 7:42015, (2017).