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Benzomalvin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Benzomalvin A图片
CAS NO:157047-96-6
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Benzomalvin A 是一种从青霉分离的神经激肽受体的强效拮抗剂。
Cas No.157047-96-6
Canonical SMILESO=C1N2C(C(CC3=CC=CC=C3)N(C)C(C4=C2C=CC=C4)=O)=NC5=CC=CC=C51
分子式C24H19N3O2
分子量381.4
溶解度DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Benzomalvin A is a fungal metabolite produced by Penicillium. It inhibits yeast α-glucosidase in vitro (IC50 = 383.2 μM). In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P to guinea pig, rat, and human NK1 (Kis = 12, 42, and 43 μM, respectively).