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Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite图片
CAS NO:1682657-14-2
包装:1g
市场价:17068元

产品介绍
Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。
Cas No.1682657-14-2
分子式C20H37N2O6P
分子量432.49
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562