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4,9-Anhydrotetrodotoxin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4,9-Anhydrotetrodotoxin图片
CAS NO:13072-89-4
包装:100μg
市场价:3009元

产品介绍
Cas No.13072-89-4
别名4,9-anhydro-TTX
化学名(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
Canonical SMILESO[C@@]12[C@]3([H])[C@]4(N=C(N)N[C@@]([C@]45[H])([H])O3)[C@H](O)[C@@](O2)([H])[C@@](CO)(O)[C@]5([H])O1
分子式C11H15N3O7
分子量301.3
溶解度5mg/mL in Ethanol, 1mg/mL in Water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 &#181M for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.[1]

Reference:
[1]. Rosker, C., Lohberger, B., Hofer, D., et al. The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel. American Journal of Physiology.Cell Physiology 293(2), C783-C789 (2007).
[2]. Teramoto, N., and Yotsu-Yamashita, M. Selective blocking effects of 4,9-anhydrotetrodotoxin, purified from a crude mixture of tetrodotoxin analogues, on NaV1.6 channels and its chemical aspects. Mar.Drugs 13(2), 984-995 (2015).
[3]. Moczydlowski, E.G. The molecular mystique of tetrodotoxin. Toxicon 63, 165-183 (2013).