CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 μM) with little activity at ABCG1.
| Cas No. | 1942919-63-2 |
| Canonical SMILES | COC1=CC=C(C(N2C(C3=CC(Cl)=C(Cl)C=C3)C(NC4=C5C=CC=C4)=C5CC2)=O)C=C1 |
| 分子式 | C25H20Cl2N2O2 |
| 分子量 | 451.3 |
| 溶解度 | DMF: 20 mg/ml,DMF:PBS(pH7.2) (1:2): 0.33 mg/ml,DMSO: 2 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 µM) with little activity at ABCG1. It has been shown to reverse the ABCG2-mediated resistance toward SN 38 and to inhibit ATPase activity. |
m.cnreagent.com