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Nemadipine A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nemadipine A图片
CAS NO:54280-71-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Nemadipine A 是 EGL-19 L 型 Ca2+ 通道的特异性抑制剂。 Nemadipine A 是一种可渗透细胞的 L 型钙通道抑制剂,可使 TRAIL 抗性癌细胞对该配体敏感。
Cas No.54280-71-6
Canonical SMILESCC1=C(C(OCC)=O)C(C2=C(F)C(F)=C(F)C(F)=C2F)C(C(OCC)=O)=C(C)N1
分子式C19H18F5NO4
分子量419.3
溶解度DMSO: 20 mg/ml,Ethanol: 15 mg/ml,Methanol: 100 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.