您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Oligomycin D
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Oligomycin D
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Oligomycin D图片
CAS NO:1404-59-7
包装与价格：
包装价格(元)
500μg电议
2.5mg电议

产品介绍
Cas No.1404-59-7
别名芦他霉素,26-Demethyloligomycin A
化学名(1S,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione
Canonical SMILESC[C@H](C[C@H]1[C@@H](C)CC[C@@]2(C[C@@H]([C@@]([H])([C@@H](O2)CC[C@@]([H])(CC)/C=C/C=C/C[C@@H](C)[C@H](O)[C@@](O)(C3=O)C)C)OC(/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@@H]3C)=O)=O)O1)O
分子式C44H72O11
分子量777
溶解度Soluble in methanol, or in ethanol, or in DMSO, or in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. [1] Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36 &#181M.[2]

Reference:
[1]. Inoue, S., Mizutani, A., Sugita, R., et al. Purification and characterization of a novel protein activator of Ca2+/calmodulin-dependent protein kinase I. Biochemical and Biophysical Research Communications 215(3), 861-867 (1995).
[2]. Salim, A.A., Tan, L., Huang, X.-C., et al. Oligomycins as inhibitors of K-Ras plasma membrane localisation. Organic & Biomolecular Chemistry 14(2), 711-715 (2016).