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17-phenyl trinor Prostaglandin F2α-d4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
17-phenyl trinor Prostaglandin F2α-d4图片
CAS NO:58976-50-4
包装与价格：
包装价格(元)
25 μg电议
50 μg电议
100 μg电议
1mg电议

产品介绍
An internal standard for the quantification of bimatoprost (free acid)
Cas No.58976-50-4
Canonical SMILESO[C@@H](CCC1=CC=CC=C1)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O
分子式C23H28D4O5
分子量392.5
溶解度DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): .5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

17-phenyl trinor Prostaglandin F2α-d4(17-phenyl trinor PGF2α-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 17-phenyl trinor PGF2αby GC-or LC-mass spectrometry. 17-phenyl trinor PGF2αis a metabolically stable analog of PGF2αand is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.1At the rat recombinant FP receptor expressed in CHO cells 17-phenyl trinor PGF2αinhibits PGF2αbinding with a Kiof 1.1 nM.2The isopropyl ester of 17-phenyl trinor PGF2α-d4is slightly better than PGF2αisopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.3

1.Balapure, A.K., Rexroad, C.E., Jr., Kawada, K., et al.Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptorBiochem. Pharmacol.38(14)2375-2381(1989) 2.Lake, S., Gullberg, H., Wahlqvist, J., et al.Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptorFEBS Letters355317-325(1994) 3.Stjernschantz, J., and Resul, B.Phenyl substituted prostaglandin analogs for glaucoma treatmentDrugs of the Future17691-704(1992)