| CAS NO: | 362049-62-5 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 362049-62-5 |
| 别名 | O-Acetyl-L-carnitine-d3-1 hydrochloride |
| Canonical SMILES | OC(C[C@@H](OC(C([2H])([2H])[2H])=O)C[N+](C)(C)C)=O.[Cl-] |
| 分子式 | C9H15D3NO4.Cl |
| 分子量 | 242.7 |
| 溶解度 | Methanol: slightly soluble,Water: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Acetyl-L-carnitine-d3is intended for use as an internal standard for the quantification of L-acetylcarnitine by GC- or LC-MS. Acetyl-L-carnitine is an acetylated form of the essential mitochondrial metabolite L-carnitine that is catabolized by plasma esterases into carnitine.1,2,3Acetyl-L-carnitine facilitates the uptake of acetyl-CoA into mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis.In vivo, acetyl-L-carnitine (100 mg/kg) increases mGlu2/3 receptor protein levels and mechanical pain thresholds in a mouse model of chronic inflammatory pain induced by complete Freund's adjuvant.4 1.Vaz, F.M., and Wanders, R.J.A.Carnitine biosynthesis in mammalsBiochem. J.361(Pt 3)417-429(2002) 2.Fu, L., Huang, M., and Chen, S.Primary carnitine deficiency and cardiomyopathyKorean. Circ. J.43(12)785-792(2013) 3.Stieger, B., O'Neill, B., and KrÄhenbÜhl, S.Characterization of L-carnitine transport by rat kidney brush-border-membrane vesiclesBiochemistry Journal309(Pt 2)643-647(1995) 4.Notartomaso, S., Mascio, G., Bernabucci, M., et al.Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic painMol. Pain13:1744806917697009(2017) |
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