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Apelin-13(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Apelin-13(trifluoroacetate salt)图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Endogenous ligand of the APJ receptor
Canonical SMILESO=C([C@H](CCSC)NC(C1N(C(CNC([C@H](CCCCN)NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H]2N(C([C@@H](NC([C@@H](N)CCC(N)=O)=O)CCCNC(N)=N)=O)CCC2)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)CCC1)=O)N4[C@H](C(N[C@H](C(O)=O)CC5=CC=CC=C5)=O)CCC4.OC(C(F)(F)F)=O
分子式C69H111N23O16S.XCF3COOH
分子量1550.8
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50value of 0.37 nM (the EC50values for apelin-17 and apelin-36 are 2.5 and 20 nM, respectively).1,2It acts primarily in the periphery and central nervous system, playing important roles in regulating cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity.3Unlike apelin-36, apelin-13 poorly blocks the entry of human immunodeficiency virus into cells.4

1.Tatemoto, K., Hosoya, M., Habata, Y., et al.Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptorBiochemical and Biophysical Research Communications251471-476(1998) 2.Lee, D.K., Cheng, R., Nguyen, T., et al.Characterization of apelin, the ligand for the APJ receptorJournal of Neurochemistry7434-41(2000) 3.Kleinz, M.J., and Davenport, A.P.Emerging roles or apelin in biology and medicinePharmacology & Therapeutics107198-211(2005) 4.Zou, M.X., Liu, H.Y., Haraguchi, Y., et al.Apelin peptides block the entry of human immunodeficiency virus (HIV)FEBS Letters47315-18(2000)