| CAS NO: | 153466-65-0 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 153466-65-0 |
| 别名 | 双氯芬酸 D4 |
| Canonical SMILES | ClC1=C(N([H])C2=C(CC(O)=O)C([2H])=C([2H])C([2H])=C2[2H])C(Cl)=CC=C1 |
| 分子式 | C14H7D4Cl2NO2 |
| 分子量 | 300.2 |
| 溶解度 | DMSO: 35 mg/ml,Ethanol: 35 mg/ml,PBS (pH 7.2): 6 mg/ml,Water: 50 mg/ml |
| 储存条件 | Store at Room temperature |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Diclofenac-d4contains four deuterium atoms on the benzene ring. It is intended for use as an internal standard for the quantification of diclofenac by GC- or LC-mass spectrometry. Diclofenac is a non-selective COX inhibitor.1,2,3It inhibits human COX-1 and -2 with IC50values of 0.9-2.7 and 1.5-20 µM, respectively.1,2Diclofenac inhibits ovine COX-1 and -2 with IC50values of 60 and 220 nM, respectively.3 1.Laneuville, O., Breuer, D.K., DeWitt, D.L., et al.Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugsJ. Pharmacol. Exp. Ther.271(2)927-934(1994) 2.Barnett, J., Chow, J., Ives, D., et al.Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus systemBiochim Biophys. Acta.1209(1)130-139(1994) 3.Johnson, J.L., Wimsatt, J., Buckel, S.D., et al.Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledonsArch. Biochem. Biophys.324(1)26-34(1995) |
m.cnreagent.com