| CAS NO: | 1219798-88-5 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 1219798-88-5 |
| 别名 | 多奈哌齐-D4,E2020-d4 |
| Canonical SMILES | O=C1C(C([2H])([2H])C2CCN(C([2H])([2H])C3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.Cl |
| 分子式 | C24H25D4NO3.HCl |
| 分子量 | 420 |
| 溶解度 | DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 0.5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Donepezil-d4(hydrochloride) is intended for use as an internal standard for the quantification of donepezil by GC- or LC-MS. Donepezil is a reversible acetylcholinesterase inhibitor (IC50= 23 nM) that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.1As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil has been used to study cognition, memory, and behavior in animal models.2,3 1.MuÑoz-Torrero, D.Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's diseaseCurr. Med. Chem.152433-2455(2008) 2.Ramalingayya, G.V., Nampoothiri, M., Nayak, P.G., et al.Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasksPharmacogn. Mag.12(Suppl 1)S63-S70(2016) 3.Shumizu, S., Mizuguchi, Y., Sobue, A., et al.Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in miceJ. Pharmacol. Sci.127(4)439-445(2015) |
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