Galantamine-d₃is intended for use as an internal standard for the quantification of galantamine by GC- or LC-MS. Galantamine is an alkaloid originally isolated from the bulbs and flowers ofGalanthusthat inhibits acetylcholinesterase (AChE; IC₅₀= 636 nM).¹It reverses growth inhibition and inhibits apoptosis, autophagic flux, and production of reactive oxygen species (ROS) induced by amyloid-β (Aβ) in neuronally differentiated PC12 cells.²Galantamine prevents soman toxicity and inhibits acetylcholinesterase in cynomolgus macaques (ED₅₀s = 590 and 362 μg/kg, respectively).³It also decreases escape latency in the Morris water maze and the total hippocampal area of Aβ plaques in an APP/PS1 transgenic mouse model of Alzheimer's disease.⁴

1.Rook, Y., Schmidtke, K.U., Gaube, F., et al.Bivalent β-carbolines as potential multitarget anti-Alzheimer agentsJournal of Medicinal Chemistry53(9)3611-3617(2010) 2.Jiang, S., Zhao, Y., Zhang, T., et al.Galantamine inhibits β-amyloid-induced cytostatic autophagy in PC12 cells through decreasing ROS productionCell Prolif.51(3)e12427(2018) 3.Hamilton, L.R., Schachter, S.C., and Myers, T.M.Time course, behavioral safety, and protective efficacy of centrally active reversible acetylcholinesterase inhibitors in cynomolgus macaquesNeurochem. Res.42(7)1962-1971(2017) 4.Wu, Z., Zhao, L., Chen, X., et al.Galantamine attenuates amyloid-β deposition and astrocyte activation in APP/PS1 transgenic miceExp. Gerontol.72244-250(2015)