| CAS NO: | 1217448-19-5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1217448-19-5 |
| Canonical SMILES | O=C(N[C@@H](CC1CCCCC1)C(N[C@H](C(NC2=CC(OC(C=C3C)=O)=C3C=C2)=O)CCCCN)=O)OCC4C(C=CC=C5)=C5C6=C4C=CC=C6.OC(C(F)(F)F)=O |
| 分子式 | C40H46N4O6.CF3COOH |
| 分子量 | 792.9 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Galnon is a galanin (GAL) receptor agonist (KD= 2.9 µM in Bowes cells expressing GAL1receptors).1It inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC50= 10 µM). Galnon (2 mg/kg) reduces the maximal seizure score and increases the latency to first seizure in a mouse model of seizure induced by pentylenetetrazole . It reduces cocaine-induced motor activity and frontal cortex, but not nucleus accumbens, dopamine overflow, as well as blocks cocaine-primed reinstatement of cocaine-seeking behavior in rats.2Galnon (1.5-5 mg/kg) reduces food intake in rats and mice.3 1.Saar, K., Mazarati, A.M., Mahlapuu, R., et al.Anticonvulsant activity of a nonpeptide galanin receptor agonistProc. Natl. Acad. Sci. USA99(10)7136-7141(2002) 2.Ogbonmwan, Y.E., Sciolino, N.R., Groves-Chapman, J.L., et al.The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortexAddict. Biol.20(4)701-713(2015) 3.Abramov, U., FlorÉn, A., Echevarria, D.J., et al.Regulation of feeding by galnonNeuropeptides38(1)55-61(2004) |
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