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(E/Z)-IT-603
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(E/Z)-IT-603图片
CAS NO:292168-90-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
(E/Z)-IT-603是E-IT-603和Z-IT-603(IT-603)的混合物。IT-603是一种c-Rel抑制剂,其IC50值为3μM。IT-603具有抗癌活性。(E/Z)-IT-603有望作为调节剂调节移植物抗宿主病和恶性病中的T细胞反应。
Cas No.292168-90-2
别名5-(5-溴-2-羟基-3-甲氧基亚苄基)-2-硫代咪唑烷-4-酮
Canonical SMILESO=C(/C(N1)=C\C2=CC(Br)=CC(OC)=C2O)NC1=S
分子式C11H9BrN2O3S
分子量329.17
溶解度DMSO: 125 mg/mL (379.74 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1].

[1]. Yusuke Shono, et al. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Discov. 2014 May; 4(5): 578-591.