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Captopril
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Captopril图片
CAS NO:62571-86-2
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
500mg电议

产品介绍
Captopril (SQ 14225) 是一种抗高血压药，是一种含硫醇的竞争性口服活性血管紧张素转换酶 (ACE) 抑制剂 (IC50=0.025 μM)，已广泛用于高血压和充血性心力衰竭的研究。
Cas No.62571-86-2
别名卡托普利; SQ 14225
化学名(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
Canonical SMILESCC(CS)C(=O)N1CCCC1C(=O)[O-]
分子式C9H15NO3S
分子量217.3
溶解度≥ 21.7 mg/mL in DMSO, ≥ 105.2 mg/mL in EtOH with ultrasonic, ≥ 48.6 mg/mL in Water with ultrasonic
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Captopril is an inhibitor of Angiotensin-I-converting enzyme (ACE) with IC50 value of 6nM [1].

Captopril is an old drug with antihypertensive efficacy commonly used in the control of blood pressure. Captopril is found to be an ACE inhibitor in all species studied. Administration of captopril inhibits the pressor response to intravenously administered angiotensin I but not that induced by angiotensin II both in normal human beings and in conscious normotensive rabbits. Captopril is proven to be a useful alternative to combination antihypertensive therapy in

the patients with resistant hypertension [2].

Captopril is also found to have anticancer activity. It can significantly reduce tumor growth without toxicity in athymic mice bearing LNM35 human lung cells xenografts. It is proven that captopril affects cell growth through inducing apoptosis [3].

References:
[1] FitzGerald RJ, Meisel H. Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Br J Nutr. 2000 Nov;84
[2] Bravo EL, Tarazi RC. Converting enzyme inhibition with an orally active compound in hypertensive man. Hypertension. 1979 Jan-Feb;1(1):39-46.
[3] Attoub S, Gaben AM, Al-Salam S, Al Sultan MA, John A, Nicholls MG, Mester J, Petroianu G. Captopril as a potential inhibitor of lung tumor growth and metastasis. Ann N Y Acad Sci. 2008 Sep;1138:65-72.