| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 100mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 5g | 电议 |
Cell lines | Mesangial cell |
Preparation Method | Mesangial cells were treated with Tretinoin (Aberela) at different concentrations. |
Reaction Conditions | 0 ~ 25 µm Tretinoin (Aberela); 0 to 24 hours |
Applications | Tretinoin (Aberela) increased catalase activity and decreased glutathione levels in a dose-and time-dependent manner, thereby preventing H2O2 -induced cell injury. In glomerular mesangial cells, Tretinoin (Aberela) increased catalase mRNA and γ-glutamylcysteine synthetase (catalytic subunit) mRNA levels. |
Animal models | Male Fischer 344 rats |
Preparation Method | The difference between the control group and the experimental group(Tretinoin (Aberela)) was observed |
Dosage form | 1 mg/kg/day Tretinoin (Aberela); Oral medicine |
Applications | In male Fischer 344 rats, Tretinoin (Aberela) at 1 mg/kg/day did not cause any toxic effects. Renal cortical protein levels were lower in Tretinoin (Aberela) -treated rats than in control animals of comparable age. |
| 产品描述 | Tretinoin (Aberela) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to activators[5]. In cultured human mesangial cells, Tretinoin (Aberela) increased the reduced glutathione content and the catalase activity in a dose- and time-dependent way, which then prevented the cytotoxicity of H2O2[1].A549 cells were incubated with free Tretinoin (Aberela) (TTN), blank nanocapsules (LNC) and Tretinoin (Aberela) -loaded lipid-core nanocapsules (TTN-LNC). TTN-LNC induced apoptosis and cell cycle arrest at the G1-phase while TTN did not. TTN-LNC showed higher cytotoxic effects than TTN on A549 cells evaluated[4].The combination of As-ODN-hTR and All-trans Tretinoin (Aberela) has a synergistic anti-tumor effect. This anti-tumor effect can be mainly attributed to apoptosis induced by a decrease in telomerase activity. Bcl-2 plays an important role in this process[7]. In male nmri mice, Tretinoin (Aberela) significantly inhibited cellular immunity and increased humoral immunity. Tretinoin (Aberela) decreased lymphocyte proliferation, decreased NBT, and interleukin-17 secretion, but increased interleukin-10 secretion[2]. In patients with facial acne, clindamycin phosphate Tretinoin (Aberela) Gel (CTG) (1.2% clindamycin phosphate, 0.025% Tretinoin (Aberela) in a gel base (Velac)) was significantly more effective than 0.025% Tretinoin (Aberela), which relayed on the anti-inflammatory efficacy of Tretinoin (Aberela)[3].The delivery of Tretinoin (Aberela) by polymeric micelles prolonged the blood circulation and enhanced the accumulation of Tretinoin (Aberela) in the tumor tissue compared with the administration of free Tretinoin (Aberela). Tumor growth was significantly delayed and the survival time of mice was prolonged following the treatment by Tretinoin (Aberela) polymeric micelles demonstrating the improved anticancer activity of Tretinoin (Aberela)[6]. References: |
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