您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Finasteride acetate
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Finasteride acetate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Finasteride acetate图片
CAS NO:222989-99-3
包装与价格：
包装价格(元)
100mg电议
200mg电议

产品介绍
Finasteride (MK-906) acetate 是一种有效的竞争性 5α-还原酶抑制剂，对 II 型 5α-还原酶的 IC50 为 4.2 nM。醋酸非那雄胺对 II 型 5α-还原酶的亲和力比对 I 型酶的亲和力高约 100 倍。醋酸非那雄胺可用于良性前列腺增生（BPH）和雄激素性脱发的研究。
Cas No.222989-99-3
别名醋酸非那雄胺; MK-906 acetate
分子式C25H40N2O4
分子量432.6
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Finasteride acetate(MK-906,Proscar and Propecia) is a specific inhibitor of 5α-reductase and a drug of synthetic used in the benign prostatic hyperplasia (BPH) and the male pattern baldness (MPB) [1].

In vivo, Finasteride acetate (MK-906, Proscar and Propecia) has been reported to significant reduce the concentration of DHT in prostatic tissue without side effects in pharmacologic experiments in rats and dogs. In addition, Finasteride acetate has shown the inhibition of 5α-reductase activity resulted in significant inhibition of DHT levels. Finasteride acetate has also shown the effect on reducing prostate volume in clinical experiments [1]. Finasteride acetate has been revealed to have the function to inhibit glucuronyl transferase in vitro test using rat prostate tissue [2].

References:
[1] Stoner E.The clinical development of a 5 alpha-reductase inhibitor, finasteride. J Steroid Biochem Mol Biol. 1990 Nov 20;37(3):375-8.
[2] Rittmaster RS1, Stoner E, Thompson DL, Nance D, Lasseter KC.Effect of MK-906, a specific 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates in normal men. J Androl. 1989 Jul-Aug;10(4):259-62.