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PHT-7,3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PHT-7,3图片
CAS NO:1614225-93-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PHT-7.3 是一种选择性的 Ras 激酶抑制因子连接增强蛋白 1 (Cnk1) PH 结构域的抑制剂,抑制突变型 KRas,但不抑制野生型 KRas 癌细胞和肿瘤的生长和信号传导。
Cas No.1614225-93-2
Canonical SMILESO=C1C2=C(C=CC=C2)C(CC3OCCCO3)=NN1CC4=NC(C5=CC=C(C)C=C5)=CS4
分子式C24H23N3O3S
分子量433.52
溶解度DMSO: 62.5 mg/mL (144.17 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain, which inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling[1]. Cnk1 PH-domain[1]

[1]. Indarte M ,et al. An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors. Cancer Res. 2019 Jun 15;79(12):3100-3111.