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Lisinopril-d5
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lisinopril-d5图片
CAS NO:1356905-39-9
包装:1mg
市场价:3704元

产品介绍
 
Cas No.1356905-39-9
别名赖诺普利D5,MK-521-d5
Canonical SMILESO=C(N1[C@H](C(O)=O)CCC1)[C@H](CCCCN)N[C@H](C(O)=O)CCC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H]
分子式C21H26D5N3O5
分子量410.5
溶解度Methanol: soluble,Water: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lisinopril-d5 is intended for use as an internal standard for the quantification of lisinopril by GC- or LC-MS. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.2 nM).1 It reduces the formation of endothelin-1 and increases nitric oxide in human vascular endothelial cells.2 Lisinopril inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 μg/kg in rat and dog, respectively).1

References
1. Patchett, A.A., Harris, E., Tristram, E.W., et al. A new class of angiotensin-converting enzyme inhibitors. Nature 288(5788), 280-283 (1980).
2. Desideri, G., Grassi, D., Croce, G., et al. Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: Evidence of an oxidant-sensitive pathway. Mediators Inflamm. 305087, (2008).