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Memantine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Memantine hydrochloride图片
CAS NO:41100-52-1
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
500mg电议
1g电议
5g电议

产品介绍

NMDA receptor antagonist

Cas No.41100-52-1
别名盐酸美金刚; D-145 hydrochloride
化学名3,5-dimethyladamantan-1-amine;hydrochloride
Canonical SMILESCC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
分子式C12H22ClN
分子量215.76
溶解度≥ 12.6mg/mL in DMSO; ≥20 mg/mL in Water
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93μM, 0.82μM and 0.47μM for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Memantine is an uncompetitive NMDA receptor antagonist. When using HEK293 cells express recombinant rat NMDA receptors, memantine shows inhibition of L-glutamate-mediated response with a dose- and voltage-dependent manner. Memantine also has a rapid unblocking kinetics [1].

Memantine is used clinically in spasticity, Parkinson's disease and Alzheimer’s disease. Memantine is found to attenuate the deleterious action of Aβ in the in vitro numerous studies. It is probably due to the decreased tau phosphorylation caused by memantine [2].

References:
[1] Bresink I, Benke T A, Collett V J, et al. Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. British journal of pharmacology, 1996, 119(2): 195-204.
[2] Danysz W, Parsons C G. Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine–searching for the connections. British journal of pharmacology, 2012, 167(2): 324-352.