| CAS NO: | 41100-52-1 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 5g | 电议 |
NMDA receptor antagonist
| Cas No. | 41100-52-1 |
| 别名 | 盐酸美金刚; D-145 hydrochloride |
| 化学名 | 3,5-dimethyladamantan-1-amine;hydrochloride |
| Canonical SMILES | CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl |
| 分子式 | C12H22ClN |
| 分子量 | 215.76 |
| 溶解度 | ≥ 12.6mg/mL in DMSO; ≥20 mg/mL in Water |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93μM, 0.82μM and 0.47μM for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1]. Memantine is an uncompetitive NMDA receptor antagonist. When using HEK293 cells express recombinant rat NMDA receptors, memantine shows inhibition of L-glutamate-mediated response with a dose- and voltage-dependent manner. Memantine also has a rapid unblocking kinetics [1]. Memantine is used clinically in spasticity, Parkinson's disease and Alzheimer’s disease. Memantine is found to attenuate the deleterious action of Aβ in the in vitro numerous studies. It is probably due to the decreased tau phosphorylation caused by memantine [2]. References: |
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