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Amiodarone HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amiodarone HCl图片
CAS NO:19774-82-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议
100mg电议

产品介绍
Amiodarone HCl 是一种基于苯并呋喃的 III 类抗心律失常药物,抑制 WT 外向IhERG 尾部,IC50 为 ~45 nM。
Cas No.19774-82-4
别名盐酸胺碘酮
化学名(2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone;hydrochloride
Canonical SMILESCCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I.Cl
分子式C25H30ClI2NO3
分子量681.77
溶解度≥ 13.8mg/mL in DMSO with gentle warming
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Amiodarone HCl is an anti-arrhythmic drug [1].

Amiodarone HCl has shown a non-competitive inhibition of the chronotropic effect of isoproterenol with a pD’ value of ~4.17. In addition, Amiodarone HCl has been reported to inhibit the norepinephrine-induced contractions in a non-competitive type with a pD’ value of about 4.06. Besides, all the results have been suggested that Amiodarone HCl does not compete with the agonists at their respective recognition sites. Amiodarone HCl has been found to be a different antagonizes types of anonists: β1-adrenergic agonists like isoproterenol, α-adrenergic agonists like norepinephrine and glucagon. Apart from these, Amiodarone HCl has exhibited tissular specificity. The adrenergic (glucagon) antagonism has been shown only on the heart and the arteries. Amiodarone HCl has noted no cpinephrine-induced lipolysis of the epididymal fat pad [1].

References:
[1] Polster P, Broekhuysen J. The adrenergic antagonism of amiodarone. Biochem Pharmacol. 1976 Jan 15;25(2):131-4.