Alternariol monomethyl ether 分离自 Anthocleista djalonensis (Loganiaceae) 的根，是该植物物种的重要分类标记。
| Cas No. | 23452-05-3 |
| 别名 | 交链孢霉甲基醚 |
| 化学名 | 3,7-dihydroxy-9-methoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one |
| Canonical SMILES | CC1=C(C2=C(C(O3)=O)C(O)=CC(OC)=C2)C3=CC(O)=C1 |
| 分子式 | C15H12O5 |
| 分子量 | 272.3 |
| 溶解度 | Dichloromethane: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 μg/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 μM in HCT116 cells). It inhibits human topoisomerase II and bacterial gyrase at initial inhibitory concentrations of 25 and 10 μM, respectively. AME selectively inhibits monoamine oxidase A (MOA-A; Ki = 0.34 μM). AME also provokes DNA damage that induces mitochondrial permeability transition pore-mediated activation of apoptosis. |
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