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all-trans-4-hydroxy Retinoic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
all-trans-4-hydroxy Retinoic Acid图片
CAS NO:66592-72-1
包装:1mg
市场价:4172元

产品介绍
Cas No.66592-72-1
别名维甲酸杂质
化学名4-hydroxy-retinoic acid
Canonical SMILESCC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)C(C)(C)CCC1O
分子式C20H28O3
分子量316.4
溶解度Chloroform: Slightly Soluble,Methanol: Slightly Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1. It binds to retinoic acid receptors (RARs) with a lower affinity than other all-trans retinoic acid metabolites (IC50s = 606, 298, and 892 nM for RARα, RARβ, and RARγ, respectively, in a radioligand binding assay). It also transactivates RARs with a lower efficacy than other metabolites (EC50s = 791, 64, and 94 nM for RARα, RARβ, and RARγ, respectively) but induces transcription of a reporter plasmid equipotently. all-trans-4-hydroxy Retinoic acid inhibits cell growth, halts the cell cycle in the G1 phase, and induces differentiation of NB4 acute promyelocytic leukemia cells (EC50 = 79.8 nM).