TN-16 是一种有效的微管聚合抑制剂，IC50 为 0.4-1.7 μM。
| Cas No. | 33016-12-5 |
| 化学名 | 3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione |
| Canonical SMILES | O=C(/C1=C(C)\NC2=CC=CC=C2)NC(CC3=CC=CC=C3)C1=O |
| 分子式 | C19H18N2O2 |
| 分子量 | 306.4 |
| 溶解度 | DMF: 12.5 mg/mL,DMSO: 20 mg/mL,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL,Ethanol: 0.25 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 uM). It blocks taxol-induced assembly of tubulin (IC50 = 6 uM) and blocks colchicine binding to tubulin. Like colchicine, TN-16 inhibits alkylation of tubulin. TN-16 induces metaphase arrest in renal cell carcinoma cells. TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells. |
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