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Apoptosis Activator 2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Apoptosis Activator 2图片
CAS NO:79183-19-0
规格:≥98%
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)306.14
FormulaC15H9Cl2NO2
CAS No.79183-19-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 61 mg/mL (199.25 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: <1 mg/mL
Other info

Synonym: Apoptosis Activator 2; MDK83190; MDK-83190; MDK 83190; AAII; N-(3,4-dichlorobenzyl) Isatin;

Chemical Name: 1-[(3,4-dichlorophenyl)methyl]-1H-indole-2,3-dione

InChi Key: KGRJPLRFGLMQMV-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2

SMILES Code: O=C1N(CC2=CC=C(Cl)C(Cl)=C2)C3=C(C=CC=C3)C1=O

实验参考方法
In vitroApoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.
In vivoN/A
FormulationN/A
DosagesN/A
AdministrationN/A
ReferencesProc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8. Epub 2003 Jun 13.
生物活性

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8.

Compounds induce apoptosis in whole cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8.

Compounds promote the oligomerization of Apaf-1. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8.

Loss of Engrailed induces neurotrophin requirement in mesDA neurons. Neural Dev. 2009 Mar 16;4:11.

Differential activation of Erk1/2 in mesDA neurons. Neural Dev. 2009 Mar 16;4:11.

Erk1/2 activation is inversely correlated with P75NTR expression. Neural Dev.2009 Mar 16;4:11.