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Cefoxitin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefoxitin图片
CAS NO:35607-66-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议

产品介绍
Cefoxitin是一种广谱的、具有抗菌活性的第二代头孢菌素。Cefoxitin对革兰氏阳性/革兰氏阴性需氧菌和厌氧菌引起的各种感染都有效。
Cas No.35607-66-0
别名头孢西丁
Canonical SMILESO=C(C(N12)=C(COC(N)=O)CS[C@]2([H])[C@@](NC(CC3=CC=CS3)=O)(OC)C1=O)O
分子式C16H17N3O7S2
分子量427.45
溶解度DMSO: 100 mg/mL (233.95 mM)
储存条件4°C, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cefoxitin is a broad-spectrum, second-generation cephalosporin with antibacterial activity. Cefoxitin is effective against a wide variety of infections caused by gram-positive or gram-negative aerobes as well as by anaerobic bacteria[1][2].

Cefoxitin has good activity against gram-positive bacteria. The MICs for several gram-positive pathogens are in the range of 1-6 μg/mL[1].Cefoxitin has shown high efficacy killing B. burgdorferi at concentration of 1.25 µM/mL[3].

Cefoxitin (20 mg/kg; i.p.; daily; for 5 days) effectively kills B. burgdorferi in vivo C3H/HeN mouse model[3]. Animal Model: Four-week-old female C3H/HeN mice[3]

[1]. E O Stapley, et al. Cefoxitin and cephamycins: microbiological studies. Rev Infect Dis. Jan-Feb 1979;1(1):73-89. [2]. R N Brogden, et al. Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1979 Jan;17(1):1-37. [3]. Venkata Raveendra Pothineni, et al. In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. Drug Des Devel Ther. 2018; 12: 2915-2921.