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FOY 251
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FOY 251图片
CAS NO:71079-09-9
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
FOY251是camostate的抗蛋白水解活性代谢物,能作为蛋白酶(proteinase)抑制剂。FOY251在细胞实验中能抑制SARS-CoV-2的感染。
Cas No.71079-09-9
Canonical SMILESO=C(O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O
分子式C17H19N3O7S
分子量409.41
溶解度DMSO: 20 mg/mL (48.85 mM; ultrasonic and adjust pH to 5 with HCl); Water:< 0.1 mg/mL (insoluble)
储存条件4℃, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FOY 251 is an anti-proteolytic active metabolite camostate , acts as a proteinase inhibitor[1][2].FOY 251 inhibit SARS-CoV-2 infection in cells assay[1][3].

FOY-251 represents a dose-dependent inhibition of equivalent current in M-1 cells[2].FOY-251 inhibits the proteolytic activity of prostasin[2].

[1]. K Beckh, et al. Elimination of the Low-Molecular Weight Proteinase Inhibitor Camostate (FOY 305) and Its Degradation Products by the Rat Liver. Res Exp Med (Berl). 1987;187(6):401-6. [2]. Ai Maekawa, et al. Camostat Mesilate Inhibits Prostasin Activity and Reduces Blood Pressure and Renal Injury in Salt-Sensitive Hypertension. J Hypertens . 2009 Jan;27(1):181-9. [3]. Markus Hoffmann, et al. Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. bioRxiv. 2020 Aug 5;2020.08.05.237651.