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Glycol chitosan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glycol chitosan图片
CAS NO:123938-86-3
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍

Glycolchitosan是一种具有亲水性乙二醇支链的壳聚糖衍生物。Glycolchitosan增强了GlycinemaxHarosoy63W细胞的膜通透性和渗漏。Glycolchitosan是水溶性的,生物相容性和可生物降解的。Glycolchitosan可抑制大肠杆菌,金黄色葡萄球菌和肠炎链球菌的生长,MIC值分别为4μg/mL,32μg/mL和<0.5μg/mL。

Cas No.123938-86-3
别名乙二醇壳聚糖
Canonical SMILESN[C@@H]1[C@@H](O)[C@H](O)[C@@H](COCCO)C[C@H]1O[C@@H]2[C@@H](COCCO)C[C@@H](O[C@@H]3[C@@H](COCCO)O[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)[C@H]2O.[n]
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Glycol chitosan is a chitosan derivative with hydrophilic ethylene glycol branches. Glycol chitosan enhances membrane permeability and leadkage in Glycine max Harosoy 63W cells. Glycol chitosan is water-soluble, biocompatible and biodegradable[1][2][3]. Glycol chitosan inhibits E. coli, S. aureus and S. enteritidis growths with MIC values of 4 μg/mL, 32 μg/mL and

Glycol chitosan derivatives have been successfully applied to deliver antimicrobial agents and anticancer drugs such as chemodrugs, genes, and photosensitizers (PSs), either by physical encapsulation or chemical conjugation. Glycol chitosan can be directly linked with hydrophobic drugs to generate amphiphilic compounds that can also form nanoparticles (NPs) for cell imaging and drug delivery. The use of Glycol chitosan derivatives for cell imaging and drug delivery has several advantages, including superb tumor-homing ability in the case of Glycol chitosan NPs based on enhanced permeability and retention (EPR) effect, low cytotoxicity, ease of chemical modification, great biocompatibility, and biodegradability[1].The hydrophobic modification of Glycol chitosan is already confirmed, such as Glycol chitosan bearing a 5β-cholanic acid moiety and deoxycholic acid-Glycol chitosan, could self-assemble into nanoparticles, acting as a promising vehicle for hydrophobic drugs and genes[2].

References:
[1]. Lin F, et al. Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery. Molecules. 2019 Nov 29;24(23). pii: E4371.
[2]. Yu A, et al. Mucoadhesive dexamethasone-glycol chitosan nanoparticles for ophthalmic drug delivery. Int J Pharm. 2020 Feb 15;575:118943.
[3]. Young DH, et al. Effect of Chitosan on Membrane Permeability of Suspension-Cultured Glycine max and Phaseolus vulgaris Cells. Plant Physiol. 1982 Nov;70(5):1449-54.
[4]. Stephen Inbaraj B, et al.Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan.Sci Technol Adv Mater. 2012 Feb 2;13(1):015002.